' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 28 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Milk Thistle Extract (Silybum marianum)(Fruit/Seeds) (Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
†
Turmeric (Curcuma longa) (Root)
700 mg
†
Top Medical Research Studies
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9.5
Liver function restored
My nephew experienced a spike in liver function tests, raising concerns of an autoimmune disorder. However, after using silymarin, his liver tests returned to normal, much to our relief. This product clearly supports liver health effectively.
Read More
9.5
Effective liver detox
I find this product to be excellent. The capsules are a good size, and over the past week, I've noticed significant benefits for my liver. It promotes a thorough detox, and I've already seen visible effects. I plan to order a second package soon.
Read More
9.5
Maintained liver health
Having suffered from HELLP syndrome with near liver rupture during childbirth, I'm required to monitor my liver closely. This Silymarin supplement keeps my liver in excellent condition, as confirmed by my doctor. I take it daily to manage any discomfort, and it has been instrumental in maintaining my liver health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
Silymarin boosts insulin production
Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model.
Highly relevant diabetes treatment insight
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients.
Relevant findings for immune modulation.
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.4
9.5
Improved digestion
I'm convinced those who didn't experience digestive benefits from these capsules likely didn't take them properly. After taking two capsules twice daily for just three days, I felt increased energy and positivity. I've been using it for a month now and plan to order more! This supplement has truly aided my digestion and energy levels.
Read More
9.5
Liver function restored
My nephew experienced a spike in liver function tests, raising concerns of an autoimmune disorder. However, after using silymarin, his liver tests returned to normal, much to our relief. This product clearly supports liver health effectively.
9.5
Effective liver detox
I find this product to be excellent. The capsules are a good size, and over the past week, I've noticed significant benefits for my liver. It promotes a thorough detox, and I've already seen visible effects. I plan to order a second package soon.
9.5
Maintained liver health
Having suffered from HELLP syndrome with near liver rupture during childbirth, I'm required to monitor my liver closely. This Silymarin supplement keeps my liver in excellent condition, as confirmed by my doctor. I take it daily to manage any discomfort, and it has been instrumental in maintaining my liver health.
Read More
9.5
Restores digestion
I highly recommend this dietary supplement for anyone with gastrointestinal issues. It's 100% natural and effectively normalises digestion. After four years of use, I have completely forgotten about other digestive aids like Mezim and Creon since taking this product has been transformative.
Read More
